General description
Trifluoroacetic acid is widely used in organic synthesis as a solvent, catalyst and reagent. It is a strong acid and low boiling point reagent. It can be used as a catalyst for a variety of reactions such as rearrangements, functional group deprotections, oxidations, reductions, condensations, hydroarylations and trifluoromethylations.
Application
Trifluoroacetic acid can be used as a catalyst
- In the direct conversion of cyclohexanone to caprolactam using acetonitrile as the additive.
- In the synthesis of 1,2,4,5-tetrasubstituted imidazoles by four-component condensation of benzil, aldehydes, amines, and ammonium acetate.
- In the synthesis of d-α-Tterpineo from d-limonene by Markovnikov addition followed by hydrolysis.
Features and Benefits
Trifluoroacetic acid can be used as a catalyst due to its
- High acidity
- Easy elimination
- Good solubility in organic solvent and in water.
Analysis Note
Assay (acidimetric): ≥ 99.0 %
Density (d 20 °C/ 4 °C): 1.487 - 1.490
Identity (IR): passes test
- UPC:
- 51332831
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 8082602501