TRIFLUOROTHYMINE DEOXYRIBOSIDE (C005B-294008)

Catalog No.: C005B-294008
Mfr. No.: T2255-1G
Mfr. Name: Sigma-Aldrich
Qty/UOM: 1
UOM: GM

Price: $3,488.51

List Price: $3,876.12

Application Trifluorothymidine has been used as a component of selection medium to screen thymidine kinase (TK) mutants in lymphoma cells, human lymphoblastoid :TK6 cells, and L5178Y mouse lymphoma cells. Biochem/physiol Actions

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Description
Specifications

Application

Trifluorothymidine has been used as a component of selection medium to screen thymidine kinase (TK) mutants in lymphoma cells, human lymphoblastoid TK6 cells, and L5178Y mouse lymphoma cells.

Biochem/physiol Actions

Trifluorothymidine is a thymidine analog and is light sensitive. TFT serves as a thymidine kinase substrate to study enzyme specificity and kinetics. Incorporation of phosphorylated TFT into DNA induces damage, making it useful for DNA repair studies. TFT may also be used in the inhibition of thymidylate synthase and in screening mutant thymidine kinase gene.. It elicits antitumor activity in gastrointestinal (GI) cancers and has therapeutic potential to treat herpetic keratitis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

UPC:: 51442007
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: T2255-1G
CAS:: 70-00-8

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