General description
Triphosgene [Bis(trichloromethyl)carbonate] is a versatile organic reagent used in organic synthesis alternative to phosgene. A catalytic amount of triphosgene is particularly used in chloroformylations, carbonylations, chlorinations, and dehydration reactions.
It is also commonly employed as a coupling agent in the synthesis of carbonyl compounds.
Application
Triphosgene can be employed as a reagent to prepare:
- Thiocarbonates from thiols and alcohols by one-pot, three-component reaction.
- Substituted azetidin-2-ones from acids and imines via ketene–imine cycloaddition reaction.
- Methyl (S)-2-isocyanato-3-phenylpropanoate from
L -phenylalanine methyl ester hydrochloride in the presence of sodium bicarbonate. - Acyl azides derivatives from various carboxylic acids and sodium azide.
- Immunosuppressant agent cyclosporin by solid-phase peptide synthesis.
- Allyl azides from allyl alcohols and sodium azide in one pot method.
- Esterification coupling reagent di-2-thienyl carbonate, from 2(5H)-thiophenone.
- 2-Chloronicotinaldehydes via cyclization of the corresponding enamides.
- UPC:
- 51451501
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 330752-100G
