TUG-469 (C09-1182-868)

TUG-469 is a selective free fatty acid receptor 1 ( FFA1/GPR40 ) agonist with an EC 50 value of 19 nM. TUG-469 is >200-fold selective for FFA1 over FFA4. TUG-469 significantly improves glucose tolerance in pre-diabetic mice. TUG-469 can be used for the research of diabetes.In VitroTUG-469 (0-10 μM) shows efficacy to hFFA1 with a pEC 50 value of 7.73. TUG-469 (10 μM) increases the insulin secretion under 10 mM glucose stimulation. TUG-469 (0-100 μM) is >200-fold selective for FFA1 over FFA4 with EC 50 values of 19 nM and 4.4 μM for FFA1 and FFA4, respectively. TUG-469 (5 μM; 30 min) significantly increases insulin secretion of INS-1 cells with the presence of high glucose concentration (16.7 mM). MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoTUG-469 (5 mg/kg; i.p.; 60 and 90 min after glucose administration) affects blood glucose level. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male NZO mice with glucose administrationDosage: 5 mg/kg Administration: Intraperitoneal injection; 5 mg/kg; 60 and 90 min after glucose administration Result: Reduced the blood glucose level.Form:Solid. Specification: 0.99 Molecular Formula: C23H23NO2 Molecular Weight: 345.43 PubChem CID: 46941175 Isomeric SMILES: CC1=CC=CC=C1C2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O