TVB-3664

InformationTVB-3664 TVB-3664 is a potent, selective, orally active and reversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.018 μM and 0.012 μM for human and mouse cell palmitate synthesis, respectively.TargetsFASN (mouse cell palmitate synthesis); FASN (human cell palmitate synthesis) 0.012 μM; 0.018 μMIn vitroTVB-3664 induces FASN inhibition with significantly reduced tubulin palmitoylation and mRNA expression. Disrupted microtubule organization in tumor cells is an additional consequence of FASN inhibition. TVB-3664 combined with taxane treatment enhances inhibition of in vitro tumor cell growth compared to treatmentwith either agent alone.In vivoIn lung, ovarian, prostate, and pancreatic tumor xenograft studies, TVB-3664 and paclitaxel or docetaxel combine to inhibit xenograft tumor growth with significantly enhanced anti-tumor activity. Tumor regression is observed in 3 of 6 tumor xenograftmodels.Cell Research(from reference)Cell lines：Calu-6 cells, A549 cells Concentrations：50 nM Incubation Time：48 h, 72 h. Specifications and Purity: 99%. Molecular Formula: C25H23F3N4O2. Molecular Weight: 468.47. PubChem CID: 129101638.