TVB-3664 (C09-1510-183)

Information:TVB-3664 TVB-3664 is a potent, selective, orally active and reversible inhibitor of fatty acid synthase (FASN) with IC50 of 0.018 μM and 0.012 μM for human and mouse cell palmitate synthesis, respectively.Targets:FASN (mouse cell palmitate synthesis): FASN (human cell palmitate synthesis) 0.012 μM: 0.018 μM:In vitro:TVB-3664 induces FASN inhibition with significantly reduced tubulin palmitoylation and mRNA expression. Disrupted microtubule organization in tumor cells is an additional consequence of FASN inhibition. TVB-3664 combined with taxane treatment enhances inhibition of in vitro tumor cell growth compared to treatmentwith either agent alone.In vivo:In lung, ovarian, prostate, and pancreatic tumor xenograft studies, TVB-3664 and paclitaxel or docetaxel combine to inhibit xenograft tumor growth with significantly enhanced anti-tumor activity. Tumor regression is observed in 3 of 6 tumor xenograftmodels.Cell Research(from reference):Cell lines：Calu-6 cells, A549 cells :Concentrations：50 nM :Incubation Time：48 h, 72 h Specifications and Purity: 99% Molecular Formula: C25H23F3N4O2 Molecular Weight: 468.47 PubChem CID: 129101638