Umbralisib hydrochloride (C09-1184-311)

Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε ( CK1ε ) inhibitor, with EC 50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseachIn VitroUmbralisib hydrochloride causes a half-maximal inhibition of human whole blood CD19 cell proliferation between 100-300 nM. Umbralisib hydrochloride (10 nM-100 μM) inhibits phosphorylated AKT at Ser473 in a concentration-dependent manner in human lymphoma and leukemia cell lines . Umbralisib hydrochloride (15-50 μM) potently represses the expression of c-Myc in the DLBCL cell line LY7, and is uniquely characterized with structural features suitable for targeting CK1ε in lymphoma cells . MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoUmbralisib hydrochloride (150 mg/kg, daily p.o.) significantly shrinks the tumors by day 25 in a subcutaneous xenograft model of T-cell acute lymphoblastic leukemia (T-ALL) in NOD/SCID mice using the MOLT-4 cell line. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:PI3Kδ 22.2 nM (EC 50 ) PI3Kδ 6.2 nM (Kd) PI3Kγ 1400 nM (Kd) PI3Kβ >10000 nM (Kd) PI3Kα >10000 nM (Kd). Specifications and Purity: 98%. Molecular Formula: C31H25ClF3N5O3. Molecular Weight: 608.01. PubChem CID: 90030289. Isomeric SMILES: C[C@@H](C1=C(C(=O)C2=C(O1)C=CC(=C2)F)C3=CC(=CC=C3)F)N4C5=NC=NC(=C5C(=N4)C6=CC(=C(C=C6)OC(C)C)F)N.Cl.