UNC3866 TRIFLUOROACETATE SALT (C005B-310717)

Catalog No.: C005B-310717
Mfr. No.: SML2408-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $326.21

List Price: $362.45

Biochem/physiol Actions Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1 UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively

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Description
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Biochem/physiol Actions

Antagonist of chromodomains CBX4/7 of Polycomb repressive complex 1

UNC3866 inhibits the CBX chromodomains of the Polycomb repressive complex 1 (PRC1), which is involved in transcriptional repression. UNC3866 selectively targets CBX4 and CBX7 most potently, with Kd values of ∼100 nM. The PRC1 chromodomains facilitate PRC1-mediated transcriptional repression by targeting the complex to Trimethyllysine 27 on histone 3 (H3K27me3). UNC3866 antagonizes the methyllysine (Kme) reading function, and has been shown to inhibit the PC3 prostate cancer cell proliferation associated with CBX7 overexpression.

UPC:: 51183707
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML2408-5MG

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