Ustekinumab (anti-IL-12&IL-23) (C09-1515-446)

Ustekinumab (anti-IL-12&IL-23) 是一种抗 IL-12/IL-23 的人源单克隆 IgG1κ 抗体。:62、英文描述:Ustekinumab (anti-IL-12&IL-23) is an anti-IL-12/IL-23 IgG1κ human monoclonal antibodyPurity:≥95% (SDS-PAGE&SEC):Endotoxin Level:≤1.0EU/mg:Protein Function:IL-12: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.IL-23: Associates with IL12B to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis. Specification: Low Endotoxin, Azide Free, Validated, Recombinant, Carrier Free, ≥95%(SDS-PAGE&SEC), Lot by Lot Molecular Weight: 145625.97