General description
An 11-amino acid peptide derived from the second Ig-like domain of vascular endothelial growth factor receptor-1 (VEGFR-1 or Flt-1) that is reported to inhibit angiogenesis in chick chorioallantoic membrane and VEGF-induced vascular permeability. Does not bind to vascular endothelial growth factor (VEGF) nor inhibit its binding to VEGFR. Reported to form a stable β-sheet structure and exists as a dimer in solution.
An 11-amino acid peptide derived from the second Ig-like domain of vascular endothelial growth factor receptor-1 (VEGFR-1 or Flt-1) that is shown to inhibit angiogenesis in chick chorioallantoic membrane and inhibits VEGF-induced vascular permeability. Neither binds to vascular endothelial growth factor (VEGF) nor inhibits its binding to VEGFR. Reported to form a stable β-sheet structure and exists as a dimer in solution.
Biochem/physiol Actions
Cell permeable: no
Primary Target
VEGF
Product does not compete with ATP.
Reversible: no
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Sequence
H-Asn-Ile-Thr-Val-Thr-Leu-Lys-Lys-Phe-Pro-Leu-OH
Other Notes
Tan, D.C., et al. 2001. FEBS Lett.494, 150.
Legal Information
Sold under license of U.S. Patent 6,200,954.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Molecular Weight: 1273.56. Empirical Formula: C61H104N14O15. Quality Level: 100. Assay: ≥. 95% (HPLC). form: lyophilized solid. manufacturer/tradename: Calbiochem®. . storage condition: OK to freeze, desiccated (hygroscopic). color: white. solubility: acetonitrile: 20%, DMSO: 5 . mg/mL. shipped in: ambient. storage temp.: 2-8°C. Storage Class Code: 11 - Combustible Solids. WGK: WGK 1. Flash Point(F): Not applicable. Flash Point(C): Not applicable.- UPC:
- 12352200
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 676493-1MG