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(+/-)-verapamil hydrochloride (c15-1694-687)

(+/-)-VERAPAMIL HYDROCHLORIDE =99% (TITRATION) POWDER (C15-1694-687)

Catalog No.
C15-1694-687
Mfr. No.
V4629-10G
Mfr. Name
Sigma-Aldrich
Qty/UOM
10
UOM
GM
Price: $1,416.42
List Price: $1,573.80

Application Verapamil hydrochloride has been used: to inhibit calcium oscillation in fertilized oocyte to block calcium channel, thereby blocking the action of IL-1β: (interleukin-1β:), resulting in membrane depolarization to

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Application

Verapamil hydrochloride has been used:

  • to inhibit calcium oscillation in fertilized oocyte
  • to block calcium channel, thereby blocking the action of IL-1β (interleukin-1β), resulting in membrane depolarization
  • to investigate the effect of verapamil on cytotoxicity of 1,3-dilinoleoylglycerol (DLG)

Biochem/physiol Actions

α1-adrenoceptor antagonist; L-type calcium channel blocker. Blocks L-type Ca2+ channels in smooth and cardiac muscle, induces apoptosis of human primary and metastatic colon adenocarcinoma cells in vitro. Drug resistance reversal agent acting on Pgp, e.g. decrease renal tubule elimination of digoxin. Increases basal ATPase activity of Pgp. Substrate of Cyp3A4 and CYP2C6.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Pfizer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Shipping Information:

Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.

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UPC:
51435000
Condition:
New
Availability:
3-5 Days
Weight:
1.00 Ounces
HazmatClass:
Yes
MPN:
V4629-10G
CAS:
152-11-4

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