General description
Vincristine sulfate is an alkaloid present in Cantharanthus roseus.
Application
Vincristine sulfate has been used:
- as a positive control in potato disc anti-tumor bioassay
- as a standard cytotoxic agent
- to treat cells for manipulation of the microtubule network
Widely used in cancer research. In studies on multi-drug resistance. Used to inhibit cell cycle progression at M-phase. Used to inhibit monoamine oxidase (MAO).
Biochem/physiol Actions
Vincristine sulfate possesses antitumor action targeting cell cycle. It prevents the action of tubulin by inhibiting microtubule polymerization. It also causes cell death and blocks metaphase in mitosis by preventing chromosome segregation. Vincristine sulfate inhibits angiogenesis mediated by factors such as vasculature endothelial growth factor. It decreases vascularization in tumors and normal tissues.
Shipping Information:
Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.
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- UPC:
- 51171654
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- MPN:
- V8388-5MG
- CAS:
- 2068-78-2
