VT104 is a potent and orally active YAP/TAZ inhibitor. VT104 prevents palmitoylation of endogenous TEAD1 and TEAD3 proteins. VT104 can be used in research of cancer.In VitroVT104 (0-1000 nM) inhibits proliferation of NF2 mutant/defective cell line. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoVT104 (0.3-3 mg/kg; p.o.; NCI-H226-tumor bearing mice) blocks growth of NF2-deficient mesothelioma xenografts . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: NCI-H226-tumor bearing mice Dosage: 0.3, 1, and 3 mg/kg Administration: Oral administration Result: Blocked NCI-H226 tumor growth in mice in dose-dependent manner.Form:Solid. Molecular Formula: C25H19F3N2O. Molecular Weight: 420.43.
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- V646898-1mg
- CAS:
- 2417718-25-1
- Product Size:
- 1mg
