InformationVU 0361737 is a selective positive allosteric modulator (PAM) formGlu4receptor withEC50of 240 nM and 110 nM at human and rat receptors, respectively, displays weak activity at mGlu5 and mGlu8 receptors, is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7In vitroVU0361737 is inactive at mGlu1, mGlu2, mGlu3, mGlu6 and mGlu7 receptors and displays weak activity at mGlu5 and mGlu8 receptors.In vivoVU0361737 shows high in vivo CL in rat, a short half-life (T1/2 20 min), and demonstrates significant brain exposure (brain-to-plasma ratio of 4.1).Cell Datacell lines：Concentrations：Incubation Time：Powder Purity:≥100%. Specification: 10mM in DMSO Molecular Formula: C13H11ClN2O2 Molecular Weight: 262.69
- UPC:
- 12352005
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- V408336-1ml
- CAS:
- 1161205-04-4
- Product Size:
- 1ml
