VU6012962 is an orally bioavailable and CNS-penetrant metabotropic glutamate receptor 7 negative allosteric modulator ( mGlu 7 NAM) with an IC 50 of 347 nMIn VitroVU6012962 is highly selective for mGlu7 versus the other seven mGlu receptor subtypes. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoVU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety in the elevated zero maze (EZM) assay in mice . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: C57Bl/6J male mice (8 weeks old) Dosage: 1, 3, and 10 mg/kg Administration: I.p. injections; 60 minutes prior to testing Result: Increased total time spent in the open arms at a dose of 3 mg/kg. 10 mg/kg did cause a decrease in overall locomotion.Form:SolidIC50& Target:mGlu7 347 nM (IC 50 ). Specification: 0.99 Molecular Formula: C21H19F3N4O4 Molecular Weight: 448.4 PubChem CID: 137321168 Isomeric SMILES: COC1=C(C=CC(=C1)C(=O)NC2=C(C=CC(=C2)OC(F)(F)F)N3C=NC=N3)OCC4CC4
- UPC:
- 51183702
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- V650842-5mg
- CAS:
- 2313526-86-0
- Product Size:
- 5mg
