InformationWAY-262611 WAY-262611 (BML-WN110, Compound 5) is a beta-catenin (β-Catenin) agonist that increases bone formation rate with EC50 of 0.63 μM in TCF-Luciferase assay. WAY-262611 is also an inhibitor of dickkopf 1 (DKK1) .TargetsDKK1 ; β-Catenin (TCF-Luciferase assay) ; 0.63 μM(EC50)In vitroWAY-262611, the DKK1 inhibitor, blocks DKK1 and restores the GDF5 reduced MMP13 gene expression.In vivoWAY-262611 has excellent pharmacokinetic properties and shows a dose dependent increase in the trabecular bone formation rate in ovariectomized rats following oral administration.Cell Research(from reference)Cell lines：Surplus human chondrocytes Concentrations：0.01 μM, 0.1 μM, 1 μM Incubation Time：21 days. Specification: 0.99 Molecular Formula: C20H22N4 Molecular Weight: 318.42 PubChem CID: 25199517 Isomeric SMILES: C1CN(CCC1CN)C2=NC=CC(=N2)C3=CC4=CC=CC=C4C=C3 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/W414491-SCI_e6cf4aca63211654fd0ed9938f8f6bad.pdf
- UPC:
- 51183702
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- W414491-50mg
- CAS:
- 1123231-07-1
- Product Size:
- 50mg
- Hazard Statement Codes:
- H302:H315:H319:H335
- Precautionary Statement Codes:
- P261:P305+P351+P338
