WEE1-IN-3 is a potent Wee1 kinase inhibitor with an IC 50 of <10 nM. WEE1-IN-3 has anticancer activitiesIn VitroWEE1-IN-3 (example 1) inhibits cancer cell growth with IC 50 values of 100-1000 nM and <100 nM for SW480 cells and H23 cells, respectively./nWEE1 kinase plays a role in the G2-M cell-cycle checkpoint arrest for ΌΝΑ repair before mitotic entry. Normal cells repair damaged DNA during GI arrest. Cancer cells often have a deficient G i-S checkpoint and depend on a functional G2-M checkpoint for DNA repair. WEE1 is overexpressed in various cancer types. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:IC50: <10 nM (Wee1 kinase). Specifications and Purity: 98%. Molecular Formula: C28H31N7O2. Molecular Weight: 497.59. PubChem CID: 137471996. Isomeric SMILES: CC(C)(C1=NC(=CC=C1)N2C3=NC(=NC=C3C(=O)N2CC=C)NC4=CC5=C(C=C4)C6(CC6)CN(C5)C)O.
- UPC:
- 12352208
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- W648627-10mg
- CAS:
- 2272976-28-8
- Product Size:
- 10mg
