WEE1-IN-5 is a potent WEE1 inhibitor with an IC 50 value of 0.8 nM. WEE1-IN-5 inhibits phospho-CDC2. WEE1-IN-5 abrogates the G2 check point, increasing sensitivity to DNA damaging agents in cancer cells. WEE1-IN-5 can be used for researching anticancerIn VitroWEE1-IN-5 exhibits an EC 50 of 188 nM in pCDC2 and an IC 50 shift for CYP3A4/5. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoWEE1-IN-5 (5mg/kg for PO; 1 mg/kg for IV; single dosage) exhibits a CL of 14 mL/min/kg, an AUC int 1324 h·ng/mL and bioavailability of 35% in SD rats . MCE has not independently confirmed the accuracy of these methods. They are for reference only.IC50& Target:IC 50 : 0.8 nM (WEE1), 188 nM (CDC2). Specifications and Purity: 10mM in DMSO. Molecular Formula: C26H28Cl2N6O. Molecular Weight: 511.45.
- UPC:
- 12352208
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- W655591-1ml
- CAS:
- 2243882-74-6
- Product Size:
- 1ml
