General description
A pyrrolocarbazole compound that acts as a potent, ATP-binding site-targeting inhibitor of Wee1 (IC50 = 59 nM) with a ~590-fold selectivity over the related checkpoint kinase Chk1 (IC50 = 35 µM).
Biochem/physiol Actions
Cell permeable: no
Primary Target
Wee1
Product does not compete with ATP.
Reversible: no
Target IC50: 59 nM against Wee1
Packaging
Packaged under inert gas
Warning
Toxicity: Standard Handling (A)
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Other Notes
Palmer, B.D., et al. 2006. J. Med. Chem.49, 4896.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
- UPC:
- 51283955
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- 681641-1MG