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wee1 protein, active, 10 µg

Wee1 Protein, active, 10 µg

Sigma-Aldrich

Catalog No.
C15-1298-705
Manufacturer No.
14-925
Manufacturer Name
Sigma-Aldrich
Quantity
10
Unit of Measure
UG
Price: $788.57
List Price: $876.19

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on ′Tyr-15′.

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General description

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on ′Tyr-15′. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on ′Tyr-15′ and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

Product Source: N-terminal GST-tagged and C-terminal 6His tagged, recombinant, human Wee1 amino acids 214-end expressed by baculovirus in Sf21 insect cells.

Biochem/physiol Actions

Protein Target: WEE1

Packaging

Also available in 250μg size as catalog # 14-925M and in bulk as catalog # 14-925-K.

Quality

Routinely evaluated by phosphorylation of peptide LSNLYHQGKFLQTFCGSPLYRRR.

Other Notes

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:
41116127
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
14-925


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