InformationWZ3146 is a mutant-selective irreversible inhibitor ofEGFR(L858R)andEGFR(E746_A750)withIC50of 2 nM and 2 nM; does not inhibit ERBB2 phosphorylation (T798I).In vitroWZ3146 significantly suppresses the growth of EGFR mutation containing cell lines with IC50 of 3 nM in EGFR Del E746_A750 containing HCC827 cells, 15 nM in EGFR Del E746_A750 containing PC9 cells, 29 nM in EGFR L858R/T790M containing H1975 cells and 3 nM in EGFR Del E746_A750/T790M containing PC9 GR cells.In vivoCell Datacell lines：Concentrations：0-10 μMIncubation Time：72 hoursPowder Purity:≥99%. Specification: 10mM in DMSO Molecular Formula: C24H25ClN6O2 Molecular Weight: 464.95
- UPC:
- 51111847
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.85 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- W409245-1ml
- CAS:
- 1214265-56-1
- Product Size:
- 1ml
