XL01126 (C09-1185-426)

XL01126 is a potent degrader of LRRK2 with DC 50 s of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. XL01126 can cross blood-brain barrier and be used as a degrader probe in Parkinson’s disease research. XL01126 exerts function of study of non-cAppearance:SolidIC50& Target:DC50: 15-72 nM (LRRK2)In Vitro:XL01126 (300 nM; 4 h) exhibits strong degradation performance by forming a positively cooperative ternary complex with E3 ubiquitin ligase ligand VHL and target protein LRRK2. XL01126 (10, 30, 100 nM; 24 h) increases mitophagy in immortalized mouse eIn Vivo:XL01126 (30mg/kg; p.o.; single dose) shows oral activity with bioavailable value (F) of 15% and can penetrate the blood brain barrier after either oral or parenteral dosing in mice. Pharmacokinetic property of XL01126 in miceRoute Dose mg/kg)Biological Activity:XL01126 is a potent degrader of LRRK2 with DC 50 s of 14 nM (G2019S LRRK2) and 32 nM (WT LRRK2), respectively. XL01126 can cross blood-brain barrier and be used as a degrader probe in Parkinson’s disease research . XL01126 exerts function of study of non-. Specification: 0.99 Molecular Formula: C50H64ClFN10O6S2 Molecular Weight: 1019.69