Y-27632 dihydrochloride (C007B-316737)

Y-27632 dihydrochloride is a selective Rho-kinase inhibitor, which suppresses cholinergic nerve-mediated contractions. In addition, studies show that Y-27632 dihydrochloride increases the release of neurotransmitters from cholinergic nerves. Studies conducted on smooth muscle preparations suggest that Y-27632 dihydrochloride suppresses nerve-mediated contractile responses stimulated by acetylcholine and noradrenaline. Furthermore, studies on lung tissue damage in rats suggest that Y-27632 dihydrochloride can restore the damage caused by oleic acid by inhibition of ROCK-1 and ROCK-2. Y-27632 dihydrochloride also inhibits protein kinase C related kinase, PRK2.A cell permeable inhibitor of ROCK-1 and ROCK-2. Specification: ≥98% MDL Number: MFCD03490488 Molecular Formula: C14H21N3O·2HCl Molecular Weight: 320.26 PubChem CID: 9901617 Isomeric SMILES: C[C@H](C1CCC(CC1)C(=O)NC2=CC=NC=C2)N.Cl.Cl Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/Y129399-SCI_c6a3e9469c9ec98bed982042fc684cf1.pdf