YB-0158 (Wnt pathway inhibitor 2) is a reverse-turn peptidomimetic and a potent colorectal cancer stem cell (CSC) targeting agent. YB-0158 disrupts Sam68-Src interactions and induces apoptosis in CRC cells. Anti-cancer activitiesIn VitroYB-0158 (0.2 μM and 0.5 μM; 48 hours) significantly increases apoptosis in CRC cells as represented by activated Caspase-3/7 detection assays. YB-0158 (0.3 μM) similarly decreases CBP recruitment at the promoter of Wnt/beta-Catenin target genes LGR5 and MYC in HT29 cells, compared with DMSO control. MCE has not independently confirmed the accuracy of these methods. They are for reference only.In VivoYB-0158 displays an EC 50 (1.64 μM) in cultured MC38 cells. YB-0158 (100 mg/kg; IP; C57BL/6 mice bearing MC38 cells) shows no significant differences in primary tumor size in vivo treatments versus saline controls. MCE has not independently confirmed the accuracy of these methods. They are for reference only.Form:SolidIC50& Target:Wnt signaling. Specification: 0.99 Molecular Formula: C32H32N7Na2O7P Molecular Weight: 703.59
- UPC:
- 51171635
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Y647886-10mg
- CAS:
- 1144043-83-3
- Product Size:
- 10mg
