(Z-DEVD)2-R110

Since highly purified rhodamine 110 (R110)-derived substrates are locked in the lactone configuration they are colorless and non-fluorescent. Cleavage of R110 peptides by caspases generates strongly fluorescent R110 that can be monitored fluorimetrically at 510-530 nm with excitation of 488 nm, the most common excitation light source used in fluorescence instruments. R110-derived caspase substrates are probably the most sensitive indicators widely used for the fluorimetric detection of various caspase activities. This R110 substrate is specific for caspases 3 and 7. Our R110-based substrates are highly purified to eliminate the trace amount of free R110 that is not detectable by HPLC, but causes significant assay background.(Z-DEVD)2-R110is strongly fluorescent R110 that can be monitored fluorimetrically at 510-530 nm with excitation of 488 nm. Specification: ≥95% Molecular Formula: C72H78N10O27 Molecular Weight: 1515.44 PubChem CID: 16181078 Isomeric SMILES: CC(C)[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)NC1=CC2=C(C=C1)C3(C4=C(O2)C=C(C=C4)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)OCC5=CC=CC=C5)C6=CC=CC=C6C(=O)O3)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)OCC7=CC=CC=C7 Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/Z387827-SCI_f7bd6954b9e5b2a015c1f941cf8b7eba.pdf