Z-Val-Ala-Asp-(OMe)-Fluoromethylketone, 1mg

The novel Z-VAD(OMe)-FMK inhibitor synthesized using proprietary technology is cell permeable and irreversibly binds to activated Caspases to block apoptosis. Apoptosis is a physiological form of cell death, which plays an important role in embryogenesis, cellular homoestasis, tissue atrophy, and removal of damaged and mutated cells. Caspases, which act as molecular chainsaws, are the central components of apoptosis response. Caspases are cysteine proteases that cleave after aspartate residue in their substrates. At least 7 of 14 known mammalian caspases have important roles in apoptosis. Z-VAD(OMe)-FMK is an irreversible and cell permeable broad-spectrum Caspase Inhibitor. It has been shown to inhibit Fas-mediated apoptosis in Jurkat T cells and apoptosis in THP cells induced by diverse stimuli (including cycloheximide, thapsigargin, etoposide and staurosporine).