ZIBOTENTAN (C005B-311945)

Catalog No.: C005B-311945
Mfr. No.: SML1550-5MG
Mfr. Name: Sigma-Aldrich
Qty/UOM: 5
UOM: MG

Price: $260.50

List Price: $289.44

General description Zibotentan is an orally bioavailable, non-peptide ET A (endothelin) receptor-specific antagonist, with no activity against ET B receptor. Biochem/physiol Actions Zibotentan has been found to inhibit cell proliferation,

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Description
Specifications

General description

Zibotentan is an orally bioavailable, non-peptide ET_A (endothelin) receptor-specific antagonist, with no activity against ET_B receptor.

Biochem/physiol Actions

Zibotentan has been found to inhibit cell proliferation, invasion and metastasis in cancer models. In clinical trials on patients with castration-resistant prostate cancer and bone metastasis, who were pain-free or had mild pain, zibotentan treatment resulted in better overall survival as compared to placebo.

Zibotentan is a potent and selective endothelin ET(A) receptor antagonist with an IC₅₀ of 21 nM for the ETA receptor subtype and no binding observed even at 10,000 nM for ETB.

UPC:: 51142035
Condition:: New
Availability:: 3-5 Days
Weight:: 1.00 Ounces
HazmatClass:: No
MPN:: SML1550-5MG
CAS:: 186497-07-4

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