General description
Bicuculline is a convulsant alkaloid. It was originally isolated from the plant Dicentra cucullaria.
Application
Bicuculline has been used:
- as a compound to compare pharmacodynamics and network activity profiles of conolidine/cannabidiol
- to study the effects of chronic caffeine administration on the function of GABAA receptor
- to isolate N-methyl-D-aspartate receptor (NMDAR)-specific evoked and miniature excitatory postsynaptic currents (eEPSCs and mEPSCs) in neurons of rats
Biochem/physiol Actions
(+)-Bicuculline acts as a competitive inhibitor of GABA liganding binding to the receptor.
(+)-Bicuculline is a GABAA receptor antagonist.
Features and Benefits
This compound is featured on the GABAC Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Shipping Information:
Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.
More Information: https://cenmed.com/shipping-returns
- UPC:
- 51144601
- Condition:
- New
- Availability:
- 3-5 Days
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- MPN:
- 14340-100MG
- CAS:
- 485-49-4
