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(+)-bicuculline (c15-1243-210)

(+)-BICUCULLINE (C15-1243-210)

Catalog No.
C15-1243-210
Manufacturer No.
5058750001
Manufacturer Name
Sigma-Aldrich
Quantity
50
Unit of Measure
MG
Price: $413.27
List Price: $459.18

A potent allosteric antagonist of vertebrate GABA A receptors. Blocks GABA A -induced chloride currents in cultured neurons (IC 50 = 740 nM).

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General description

A potent allosteric antagonist of vertebrate GABAA receptors. Blocks GABAA-induced chloride currents in cultured neurons (IC50 = 740 nM). Shown to increase blood pressure in spontaneously hypertensive rats and cause convulsion in experimental animals. Also, increases the amplitude of spontaneous colonic contractions.

Warning

Toxicity: Toxic (F)

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Ueno, S., et al. 1997. J. Neurosci.17, 625.
Uchida, I., et al. 1996. Eur. J. Pharmacol.307, 89.
Minocha, A., and Galligan, J.J. 1993. Eur. J. Pharmacol.230, 187.
Robert K.A., et al. 1993. Cardiovasc. Pharmacol.21, 156.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

UPC:
51284601
Condition:
New
Weight:
1.00 Ounces
HazmatClass:
No
WeightUOM:
LB
MPN:
5058750001


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