Sigma-Aldrich
(+)-PSI REAGENT (C005B-026098)
Application Air- and moisture-tolerant, this (+)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (−)-PSI Reagent, is also available (cat# ALD00602 ).
Description
Application
Air- and moisture-tolerant, this (+)-PSI Reagent was developed in the Baran lab for stereocontrolled synthesis of phosphorothioate oligonucleotides. The enantiomer, (−)-PSI Reagent, is also available (cat# ALD00602).
The PSI Reagents open access to thiophosphate-based nucleotide molecules with therapeutic promise as demonstrated by the Baran lab in the preparation of pure stereoisomers of cyclic dinucleotides (CDNs) and antisense oligonucleotides (ASOs).
Learn more about PI and PSI reagents
Other Notes
Unlocking P(V): Reagents for chiral phosphorothioate synthesis
PSI on OpenFlask
Legal Information
PCT/US2019/027256; U.S. Nonprovisional Patent Application #16/382,692
Specifications
- UPC:
- 51422326
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- Quantity:
- 5
- Unit of Measurement:
- GR
- MPN:
- ALD00604-5G
- CAS:
- 2245335-71-9
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