1 μm Phenylboric acid Solid Phase Magnetic Beads (Low Non-specificity) (C008B-267021)

Solid phase extraction magnetic beads combine solid phase extraction technology with magnetic separation technology, and are widely used in sample pretreatment across various applications, including environmental monitoring for pollutant detection, metabolite extraction in pharmaceutical analysis, food safety testing, and extraction of toxins or pesticide residues. The bead surface is functionalized with specific adsorption functional groups, enabling selective adsorption of target compounds through hydrophobic, electrostatic, or specific interactions. Sample preparation is rapid and straightforward, and the beads can be conveniently and quickly separated using an external magnetic field, thereby improving the efficiency and effectiveness of sample pretreatment.Aladdin offers 1 μm Phenylboronic Acid Solid Phase Extraction Magnetic Beads. The core is composed of polystyrene and iron oxide nanoparticles. The surface-modified phenylboronic acid is a unique molecule capable of specifically recognizing cis-dihydroxy compounds such as nucleosides, catechols, sugars, and glycoproteins through reversible covalent reactions. The fundamental principle of the reversible boronate ester bond formation between phenylboronic acid and cis-diols is illustrated in the figure. Under alkaline conditions, boric acid undergoes hydroxylation, being attacked by OH⁻ to form a tetrahedral boronate anion, which then undergoes an esterification reaction with the vicinal dihydroxy groups of cis-dihydroxy compounds to form stable five-membered or six-membered rings. This binding is reversible. Under acidic conditions, or when competitively bound by other cis-dihydroxy compounds, the formed five-membered or six-membered rings are readily hydrolyzed, dissociating the complex back into the original phenylboronic acid and cis-dihydroxy compounds, thereby achieving separation and enrichment. Phenylboronic acid magnetic beads can be widely used in fields such as separation and enrichment, disease diagnosis, aptamer screening, drug delivery, and biosensing.Figure 1: Affinity Principle of Phenylboronic Acid Magnetic BeadsCat. NoS1520789S1520791Product Name1 μm Phenylboric acid Solid Phase Magnetic Beads 1 μm Phenylboric acid Solid Phase Magnetic Beads (Low Non-specificity)Concentration10 mg/mL10 mg/mLParticle SizeApprox. 1 μmApprox. 1 μmSurface PotentialApprox. 25 mVApprox. 30 mVMagnetic ContentApprox. 35%–45%Approx. 35%–45%Dispersion SolventPure WaterPure WaterPrecautionsEnsure the magnetic beads are thoroughly mixed before use to prevent changes in concentration during pipetting. Avoid prolonged ultrasonication, which may damage the bead surface.

Specifications & Purity: Solid phase extraction magnetic beads combine solid phase extraction technology with magnetic separation technology, and are widely used in sample pretreatment across various applications, including environmental monitoring for pollutant detection, metabolite extraction in pharmaceutical analysis, food safety testing, and extraction of toxins or pesticide residues. The bead surface is functionalized with specific adsorption functional groups, enabling selective adsorption of target compounds through hydrophobic, electrostatic, or specific interactions. Sample preparation is rapid and straightforward, and the beads can be conveniently and quickly separated using an external magnetic field, thereby improving the efficiency and effectiveness of sample pretreatment.Aladdin offers 1 μm Phenylboronic Acid Solid Phase Extraction Magnetic Beads. The core is composed of polystyrene and iron oxide nanoparticles. The surface-modified phenylboronic acid is a unique molecule capable of specifically recognizing cis-dihydroxy compounds such as nucleosides, catechols, sugars, and glycoproteins through reversible covalent reactions. The fundamental principle of the reversible boronate ester bond formation between phenylboronic acid and cis-diols is illustrated in the figure. Under alkaline conditions, boric acid undergoes hydroxylation, being attacked by OH⁻ to form a tetrahedral boronate anion, which then undergoes an esterification reaction with the vicinal dihydroxy groups of cis-dihydroxy compounds to form stable five-membered or six-membered rings. This binding is reversible. Under acidic conditions, or when competitively bound by other cis-dihydroxy compounds, the formed five-membered or six-membered rings are readily hydrolyzed, dissociating the complex back into the original phenylboronic acid and cis-dihydroxy compounds, thereby achieving separation and enrichment. Phenylboronic acid magnetic beads can be widely used in fields such as separation and enrichment, disease diagnosis, aptamer screening, drug delivery, and biosensing.Figure 1: Affinity Principle of Phenylboronic Acid Magnetic BeadsCat. NoS1520789S1520791Product Name1 μm Phenylboric acid Solid Phase Magnetic Beads 1 μm Phenylboric acid Solid Phase Magnetic Beads (Low Non-specificity)Concentration10 mg/mL10 mg/mLParticle SizeApprox. 1 μmApprox. 1 μmSurface PotentialApprox. 25 mVApprox. 30 mVMagnetic ContentApprox. 35%–45%Approx. 35%–45%Dispersion SolventPure WaterPure WaterPrecautionsEnsure the magnetic beads are thoroughly mixed before use to prevent changes in concentration during pipetting. Avoid prolonged ultrasonication, which may damage the bead surface.

Grade: BioReagent

Storage Temperature: Store at 2-8°C;Desiccated;Do not freeze

Shipped in: Wet ice;Do not freeze

UPC:

41116113

Weight:

1.09 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

S1520791-10ml

Country of Origin:

China

Product Size:

10ml

Harmonized Tariff Code:

2931.90.90