12(S)-HPETE

12(S)-HPETE is a monoperoxide hydrogenated polyunsaturated fatty acid produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It can activate leukocyte 5-LO in human blood, thereby synthesizing 5(S)-HETE, leukotriene B4, and 5(S),12(S)-DiHETE. Rat lungs metabolize 12(S)-HpETE into 8,11,12- and 10,11,12-trihydroxyphyllotrienoic acids. 12(S)-HpETE is a mediator of various biological functions, including inducing c-fos and c-jun, activating AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response of pyramidal sensory neurons to FMRF-amide and is a potent selective inhibitor of Ca2+/calmodulin-dependent protein kinase II in the rat cerebral cortex. It can also inhibit thromboxane synthase and platelet aggregation by activating guanylate cyclase.

a fatty acid and an activator of human blood leukocyte 5-LO

Specifications & Purity: 12(S)-HPETE is a monoperoxide hydrogenated polyunsaturated fatty acid produced by the action of platelet or leukocyte 12-lipoxygenase (12-LO) on arachidonic acid. It can activate leukocyte 5-LO in human blood, thereby synthesizing 5(S)-HETE, leukotriene B4, and 5(S),12(S)-DiHETE. Rat lungs metabolize 12(S)-HpETE into 8,11,12- and 10,11,12-trihydroxyphyllotrienoic acids. 12(S)-HpETE is a mediator of various biological functions, including inducing c-fos and c-jun, activating AP-1, and endothelium-dependent vasoconstriction. It mediates the inhibitory synaptic response of pyramidal sensory neurons to FMRF-amide and is a potent selective inhibitor of Ca2+/calmodulin-dependent protein kinase II in the rat cerebral cortex. It can also inhibit thromboxane synthase and platelet aggregation by activating guanylate cyclase.

Grade: Moligand™

Molecular Formula: C20H32O4

Molecular Weight: 336.47

PubChem CID: 5280892

Isomeric SMILES: CCCCC/C=C\C[C@@H](/C=C/C=C\C/C=C\CCCC(=O)O)OO

Storage Temperature: Store at -80°C

Shipped in: Dry ice packs + Cold packs

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/H336047-SCI_84352102cbdb47f7f2baa2830eb8eec5.pdf

UPC:

51412300

Weight:

1.09 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

H336047-100μg

Country of Origin:

China

CAS:

71774-10-2

Product Size:

100μg

Harmonized Tariff Code:

2931.90.90

Hazard Statement Codes:

H225;H350

Precautionary Statement Codes:

P201;P210;P202;P233;P240;P242;P243;P281