Sigma-Aldrich
2-(4-(PIPERIDIN-4-YL)PHENYL)ACETIC ACID HYDROCHLORIDE
Application 2-(4-(Piperidin-4-yl)phenyl)acetic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation . Incorporation of rigidity into the linker region of bifunctional
Description
Application
2-(4-(Piperidin-4-yl)phenyl)acetic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.
Other Notes
Portal: Building PROTAC® Degraders for Targeted Protein Degradation
Crosslinkers for Bioconjugation
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Specifications
- UPC:
- 51471806
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- 917605-100MG
- CAS:
- 34033-52-8
- Controlled Substances and Cyanide:
- Yes
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