20-carboxy Arachidonic Acid-100 ÃÆâ¦g

20-carboxy Arachidonic acid (20-COOH-AA) is the major metabolite of 20-HETE that is produced in renal tubular epithelial, endothelial, and microvascular smooth muscle cell cultures. This ω-oxidation conversion can take place using purified alcohol dehydrogenases three and four or by microsomes containing recombinant human CYP4F3B. Like 20-HETE, 20-COOH-AA inhibits ion transport in the kidneys. It also produces vasorelaxation of porcine coronary microvessels constricted with endothelin. 20-COOH-AA binds to isolated ligand binding domains of peroxisome proliferator-activated receptor α (PPARα) (Kd = 0.87 ± 0.12 µM) and PPARγ (Kd = 1.7 ± 0.5 µM), and is a dual activator of PPARα and PPARγ in a transiently transfected COS-7 cell reporter system.

Shipping Information:

Hazmat Fee: $65.00 + applicable shipping charges are added after the order is placed.

More Information: https://cenmed.com/shipping-returns

UPC:

51162016

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

Yes

WeightUOM:

LB

MPN:

10007912-100

CAS:

79551-84-1

Controlled Substances and Cyanide:

Yes