3-Hydroxymethyl-β-carboline

3-Hydroxymethyl-β-carboline is a polyaromatic small molecule that demonstrates antagonism of the effects of benzodiazepine binding activity. 3-Hydroxymethyl-beta-carboline antagonizes the anxiolytic and anticonvulsant actions of benzodiazepines, a property common to other 3-substitued carboline compounds including the inverse agonist Ethyl β-carboline-3-carboxylate . The sedative effects of the benzodiazepines are antagonized by 3-Hydroxymethyl-beta-carboline at a dose sufficiently low to have no intrinsic effect on sleep. Higher doses of 3-Hydroxymethyl-β-carboline were shown to increase wakefulness and sleep latency, suggesting that an effect inverse to benzodiazepine sedation is presented by 3-Hydroxymethyl-beta-carboline activity.

an antagonist of benzodiazepine effects

Specifications & Purity: 3-Hydroxymethyl-β-carboline is a polyaromatic small molecule that demonstrates antagonism of the effects of benzodiazepine binding activity. 3-Hydroxymethyl-beta-carboline antagonizes the anxiolytic and anticonvulsant actions of benzodiazepines, a property common to other 3-substitued carboline compounds including the inverse agonist Ethyl β-carboline-3-carboxylate . The sedative effects of the benzodiazepines are antagonized by 3-Hydroxymethyl-beta-carboline at a dose sufficiently low to have no intrinsic effect on sleep. Higher doses of 3-Hydroxymethyl-β-carboline were shown to increase wakefulness and sleep latency, suggesting that an effect inverse to benzodiazepine sedation is presented by 3-Hydroxymethyl-beta-carboline activity.

Molecular Formula: C12H10N2O

Molecular Weight: 198.22

EC Number: 817-069-5

PubChem CID: 5353338

Isomeric SMILES: C1=CC=C2C(=C1)C3=C(N2)C=NC(=C3)CO

Storage Temperature: Room temperature

Shipped in: Normal

More Information: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/H351104-SCI_622c6220b18c89685c7f912f48e20cb5.pdf

UPC:

12142207

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

H351104-25mg

Country of Origin:

China

CAS:

65474-79-5

Product Size:

25mg

Harmonized Tariff Code:

2931.90.90

Hazard Statement Codes:

H302;H315;H319;H335

Precautionary Statement Codes:

P261;P264;P270;P271;P280;P321;P330;P302+P352;P304+P340;P305+P351+P338;P362+P364;P405;P403+P233;P501;P264+P265;P301+P317;P337+P317;P332+P317;P319