General description
4-Bromo-1-butyne is commonly used as a reactant. It serves as a source of alkyl halides for the introduction of bromo functionality into the molecule.
Application
4-Bromo-1-butyne is used as a reactant in the synthesis of:
- Macrocycles by cobalt-mediated [2+2+2] co-cyclotrimerization.
- 2,4,5-trisubstituted oxazoles by a gold-catalyzed formal [3+2] cycloaddition.
- Intramolecular 1,3-dipolar cycloaddition to synthesize 1,3,4-oxadiazoles.
- Lactones bearing alkynes for reductive cyclization in the preparation of azulene derivatives.
- Substituted α-pyrones by gold-catalyzed coupling reactions.
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- UPC:
- 51284048
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- Yes
- MPN:
- 675725-5G
- CAS:
- 38771-21-0
