4-Hydroxyquinazoline (C007B-186056)

Product Application：4-Hydroxyquinazoline is been used to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins. This compound specifically and potently inhibits PARP-1. 4-HQN demonstrates the ability to decrease activation of transcription factor NFκB and AP-1 in lipopolysaccharide-induced shock. Mechanistic studies indicate that 4-HQN activates PI3-kinase/Akt pathway in the liver, spleen, and lung and down-regulates two elements of the MAP kinase system. Additionally, this agent has been observed to decrease ischemia-reperfusion-induced increase of protein oxidation, single-strand DNA breaks, lipid peroxidation, and mitochondrial reactive oxygen species production in the reperfusion period. Specification: 10mM in DMSO Molecular Formula: C8H6N2O Molecular Weight: 146.15 PubChem CID: 135408753 Isomeric SMILES: C1=CC=C2C(=C1)C(=O)NC=N2 Beilstein Registry Number: 24143

UPC:

51173008

Condition:

New

Weight:

0.85 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

H424251-1ml

CAS:

491-36-1

Product Size:

1ml