5-FOA (5-Fluoroorotic acid), Monohydr 1g

Used as a research tool in molecular genetics. Employed in the selection of resistant strains of Saccharomyces cerevisiae that possess a mutant URA3 gene which renders them orotidine-5-phosphate decarboxylase deficient. 5-FOA is converted 5-fluorouridine monophosphate (5-FUMP) in yeast cells, which can become incorporated into RNA or metabolized to the highly toxic 5-fluoro-2-deoxyuridine monophosphate (5-FdUMP). 5-FdUMP is a potential inhibitor of thyidylate Sythase (TS), causing a cessation in DNA synthesis. Synonyms: 5-FOA; FOA, 2,6-Dihydroxy-5-fluoropyrimidine-4-carboxylic Acid; 5-Fluorouracil-4-carboxylic Acid Harmful by inhalation, in contact with skin and if swallowed. Appearance: Solid Melting Point: ~285°C

UPC:

41116134

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

WeightUOM:

LB

MPN:

40600004-3

CAS:

220141-70-8