5'-NUCLEOTIDASE/CD73 HIS-TAG

General description

5′-Nucleotidase/CD73 is glycosyl-phosphatidyl inositol (GPI)- anchored cell surface protein. Itis present in various tissues and cells including endothelial cells, epithelialcells, and subsets of B and T cells.

Application

5′-Nucleotidase/CD73 has been used as a standard in recombinanthuman CD73 assay.

Biochem/physiol Actions

5′-Nucleotidase/CD73 actsas a rate-limiting enzyme to produce adenosine. It helps in upholding tissuehomeostasis by converting the adenosine triphosphate (ATP)-triggered immuneactivation to adenosine-mediated immunosuppression.CD73 is a novel immunoinhibitory protein that participates in tumor growthand metastasis. CD73 in combination with conventional therapy and/or otherimmune checkpoint inhibitors has been reported to show therapeutic effectsagainst cancer.

Physical form

Aqueous solution

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UPC:

51112522

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

MPN:

SRP0570-50UG

Temperature Control Device:

Yes