7-Cl-O-Nec1 (C007B-391814)

InformationNecrostatin 2 racemate (Nec-1s) Necrostatin 2 racemate (Nec-1s, 7-Cl-O-Nec1, Necrostatin-1 stable, Necrostatin 1S) is a stable variant of Necrostatin-1. It is a more specific RIPK1 inhibitor lacking the IDO-targeting effect, with >1000-fold more selectiIn vitroNec-1s is a potent inhibitor of RIPK1 and cellular necroptosis while lacking IDO inhibitory activity.In vivoNec-1s is effective in reducing brain injuries. It is a superior inhibitor suitable for use in vivo lacking a paradoxical sensitizing effect in TNF-induced lethality. Nec-1s possesses several advantageous pharmacokinetic and pharmacodynamic characteristics in comparison to Nec-1. Safety profile of Nec-1s is also superior to that of Nec-1 for reduced in vivo and in vitro toxicity.Cell Datacell lines：Cell lines:Concentrations：Incubation Time：Powder Purity:≥98%. Specification: 10mM in DMSO Molecular Formula: C13H12ClN3O2 Molecular Weight: 277.71

UPC:

51111707

Condition:

New

Weight:

0.85 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

N409256-1ml

CAS:

852391-15-2

Product Size:

1ml