7ALPHA-HYDROXY-4-CHOLESTEN-3-ONE

General description

7α-Hydroxy-4-cholesten-3-one (C4) is known as a marker for the cholesterol 7α-hydroxylase activity. It plays an important role in bile acid metabolism.

Application

C4 may be used as a reference standard for the determination of C4 in:

• Human serum by ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) with electrospray ionization source (ESI) as well as LC-MS.
• Rat and monkey plasma by LC-ESI-MS/MS working on multiple reaction monitoring (MRM) mode of detection.
• Peripheral blood plasma by solid-phase extraction (SPE) and HPLC.

Biochem/physiol Actions

7a-Hydroxycholestene-3-one, a metabolite in bile acid synthesis, is derived from 7a-hydroxycholesterol and can be further metabolized to 7a,12a,-dihydroxycholest-4-en-3-one. Analysis of 7a-Hydroxycholestene-3-one (HCO) in serum may serve as a novel, simple, and sensitive method for the detection of bile acid malabsorption in patients with chronic diarrhea of unknown origin.

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UPC:

41115700

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

MPN:

52853-1MG

CAS:

3862-25-7

Temperature Control Device:

Yes