Sigma-Aldrich
8-PCPT-2'-O-ME-CAMP-AM (C005B-475075)
Biochem/physiol Actions 8-pCPT-2′:-O-Me-cAMP-AM (CPT-AM) is a membrane-permeant acetoxymethyl (AM) ester precusor form of the EPAC-selective cAMP analog (ESCA) 8-pCPT-2′:-O-Me-cAMP (CPT). CPT-AM is >:100-times more cell-permeable than
Description
Biochem/physiol Actions
8-pCPT-2′-O-Me-cAMP-AM (CPT-AM) is a membrane-permeant acetoxymethyl (AM) ester precusor form of the EPAC-selective cAMP analog (ESCA) 8-pCPT-2′-O-Me-cAMP (CPT). CPT-AM is >100-times more cell-permeable than CPT (by FRET using CFP-Epac-YFP-expressing A431; No effect by PKA FRET assay) and >100-times more efficient in stimulating cellular Rap1 activation (ECmax = 0.1 μM/CPT-AM vs. 100 μM/CPT; HUVECs).
Specifications
- UPC:
- 51180000
- Condition:
- New
- Weight:
- 1.00 Ounces
- HazmatClass:
- No
- MPN:
- SML3072-1UMO
- CAS:
- 1152197-23-3
- Controlled Substances and Cyanide:
- Yes
Catalog No.
C005B-475075
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