9-Hydroxyellipticine, Hydrochloride (C007B-184550)

9-Hydroxyellipticine, Hydrochloride is a cell-permeable antitumor alkaloid that acts as a potent inhibitor of Topo II (IC|50|= 3.3 μM). Restores functional wild-type p53 activity via inhibition of mutant p53 protein phosphorylation. Suppresses Cdk2 activity in a concentration-dependent manner. Also reported to inhibit telomerase activity in cultured pancreatic cells, possibly through inhibition of protein kinases. Binds to the aryl hydrocarbon receptor (AhR) in rat lung cytosol and inhibits aryl hydrocarbon hydroxylase (AHH) activity in rat hepatic microsomes. Specification: ≥98% Molecular Formula: C17H15ClN2O Molecular Weight: 298.77 PubChem CID: 148569 Isomeric SMILES: CC1=C2C=CN=CC2=C(C3=C1NC4=C3C=C(C=C4)O)C.Cl Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/H339157-SCI_5d3b89ac7ab6a3db650fae94e85ae21b.pdf

UPC:

12352200

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

H339157-50mg

CAS:

52238-35-4

Product Size:

50mg

Precautionary Statement Codes:

P264