9Z,11E,13E-Octadecatrienoic Acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid makes up about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. In rats, α-ESA was metabolized and converted to conjugated linoleic acid (9Z,11E-CLA). It has shown potential as a tumor suppressor. In Caco-2 colon cancer cells, α-ESA triggered apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was triggered via lipid peroxidation. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 μM for different isoforms of the enzymes.Packaging specifications based on solute content
Specifictaions: ≥98%, ~10 mg/mL in methanol
MDL Number: C18H30O2
Molecular Formula: 278.43
PubChem CID: 5281115
Isomeric SMILES: CCCC/C=C/C=C/C=C\CCCCCCCC(=O)O
Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/Z337625-SCI_435035c06b1a58b47f38a6cf6db82285.pdf
- UPC:
- 51172407
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Z337625-1mg
- CAS:
- 506-23-0
- Product Size:
- 1mg
- Physical Hazards:
- Flammable Liquid
