A conjugated polyunsaturated fatty acid commonly found in plant seed oil which accounts for about 70% in tung oil and 60% of the total fatty acid composition of bitter gourd seed oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ. In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC|50|of 20 μM. It also inhibits DNA polymerases and topoisomerases with IC|50|s ranging from ~5-20 μM for different isoforms of the enzymes. α-ESA ethyl ester is a neutral, more lipid soluble form of the free acid. Specification: 10mg/mL in ethanol Molecular Formula: C20H34O2 Molecular Weight: 306.48 PubChem CID: 12430060 Isomeric SMILES: CCCC/C=C/C=C/C=C/CCCCCCCC(=O)OCC Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/Z337626-SCI_346c749ccd691c25ab4d44664e850b89.pdf
- UPC:
- 12352002
- Condition:
- New
- Availability:
- 2 weeks
- Weight:
- 0.96 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Z337626-10mg
- CAS:
- 42021-86-3
- Product Size:
- 10mg
- Hazard Statement Codes:
- H225:H350
- Precautionary Statement Codes:
- P201:P210:P202:P233:P240:P242:P243:P281
