9Z,11E,13E-octadecatrienoic acid (α-ESA) is a conjugated polyunsaturated fatty acid commonly found in plant seed oil. This fatty acid accounts for about 60% of the total fatty acid composition of bitter gourd seed oil and about 70% in tung oil. α-ESA is metabolized and converted to conjugated linoleic acid (9Z,11E-CLA) in rats. It has shown potential as a tumor growth suppressor. In colon cancer Caco-2 cells, α-ESA induced apoptosis through up-regulation of GADD45, p53, and PPARγ.In DLD-1 cells supplemented with α-ESA, apoptosis was induced via lipid peroxidation with an EC50 of 20 µM. It also inhibits DNA polymerases and topoisomerases with IC50s ranging from ~5-20 µM for different isoforms of the enzymes. α-ESA methyl ester is a neutral, more lipid soluble form of the free acid.
Specification: ≥98%, 10mg/ml in ethanol
Molecular Formula: C19H32O2
Molecular Weight: 292.5
PubChem CID: 21718552
Isomeric SMILES: CCCC/C=C/C=C/C=C\CCCCCCCC(=O)OC
Related Documents: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/Z342825-SCI_435fadc2c9efc6f05f557e61293fbd94.pdf
- UPC:
- 12352211
- Condition:
- New
- Availability:
- 4-8 weeks
- Weight:
- 0.07 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- Z342825-10mg
- CAS:
- 4175-47-7
- Product Size:
- 10mg
- Precautionary Statement Codes:
- P281:P243:P242:P240:P233:P202:P210:P201
