A1874 (C007B-021157)

InformationA1874 is a much improved nutlin-based, BRD4-degrading PROTAC and is able to degrade its target protein by 98% with nanomolar potency.TargetsBRD4In vitroIn HCT116 cells, A1874 causes a 97% decrease in viability and in A375 cells, A1874 causes a 98% loss of viability.A1874 reduced viability of Daudi cells by 70% and of MOLM-13 cells by 95%.Cell Research(from reference)Cell lines：HCT116 cell lines Concentrations：0-10 μM Incubation Time：24 h. Specification: 0.98 Molecular Formula: C58H62Cl3F2N9O7S Molecular Weight: 1173.59 PubChem CID: 124201003 Isomeric SMILES: CC1=C(SC2=C1C(=N[C@H](C3=NN=C(N32)C)CC(=O)NCCOCCOCCOCCNC(=O)C4=CC(=C(C=C4)NC(=O)[C@H]5[C@@H]([C@@]([C@@H](N5)CC(C)(C)C)(C#N)C6=C(C=C(C=C6)Cl)F)C7=C(C(=CC=C7)Cl)F)OC)C8=CC=C(C=C8)Cl)C

UPC:

12352200

Condition:

New

Weight:

0.96 Ounces

HazmatClass:

No

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

A414180-5mg

CAS:

2064292-12-0

Product Size:

5mg