ACBI1 (C008B-271693)

ACBI1 is a potent and cooperative SMARCA2 , SMARCA4 and PBRM1 degrader with DC 50 s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosisIn VitroACBI1 (1-10000 nM； 3-7 days) shows anti-proliferative activity. ACBI1 (0.3 µM; 100 h) induces apoptosis in SK-MEL-5 cells. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase von Hippel-Lindau. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MV-4-11, NCI-H1568 cells Concentration: 0-1000 nM Incubation Time: 3-7 days Result: Showed anti-proliferative activity with IC 50 of 29, 68 nM for MV-4-11, NCI-H1568 cells, respectively. Apoptosis AnalysisCell Line: SK-MEL-5 cells Concentration: 0.3 µM Incubation Time: 100 h Result: Induced apoptosis in SK-MEL-5 cells.Form:SolidIC50& Target:DC 50 : 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)

Specifications & Purity: ACBI1 is a potent and cooperative SMARCA2 , SMARCA4 and PBRM1 degrader with DC 50 s of 6, 11 and 32 nM, respectively. ACBI1 is a PROTAC degrader. ACBI1 shows anti-proliferative activity. ACBI1 induces apoptosisIn VitroACBI1 (1-10000 nM； 3-7 days) shows anti-proliferative activity. ACBI1 (0.3 µM; 100 h) induces apoptosis in SK-MEL-5 cells. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase von Hippel-Lindau. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Proliferation AssayCell Line: MV-4-11, NCI-H1568 cells Concentration: 0-1000 nM Incubation Time: 3-7 days Result: Showed anti-proliferative activity with IC 50 of 29, 68 nM for MV-4-11, NCI-H1568 cells, respectively. Apoptosis AnalysisCell Line: SK-MEL-5 cells Concentration: 0.3 µM Incubation Time: 100 h Result: Induced apoptosis in SK-MEL-5 cells.Form:SolidIC50& Target:DC 50 : 6 nM (SMARCA2), 11 nM (SMARCA4), 32 nM (PBRM1)

Grade: Moligand™

Molecular Formula: C49H58FN9O7S

Molecular Weight: 936.10

PubChem CID: 137628619

Isomeric SMILES: CC1=C(SC=N1)C2=CC(=C(C=C2)CNC(=O)[C@@H]3C[C@H](CN3C(=O)[C@H](C(C)(C)C)NC(=O)C4(CC4)F)O)OCCOC5=CC=C(C=C5)CN6CCN(CC6)C7=CC(=NN=C7N)C8=CC=CC=C8O

Storage Temperature: Protected from light;Store at -20°C;Argon charged

Shipped in: Ice chest + Ice pads

UPC:

51171825

Weight:

1.06 Ounces

HazmatClass:

Yes

Quantity:

1

Unit of Measurement:

EA

WeightUOM:

LB

MPN:

A649179-1mg

Country of Origin:

China

CAS:

2375564-55-7

Product Size:

1mg

Harmonized Tariff Code:

2931.90.90