ADENOSINE 5'-DIPHOSPHATE SODIUM FROM BACTERIAL SOURCE (C005B-024358)

General description

Adenosine 5′-diphosphate (ADP) is an adenine nucleotide involved in energy storage and nucleic acid metabolism via its conversion into ATP by FOF1-ATP synthases. ADP can also be obtained by adenylate monophosphate (AMP) reaction catalyzed by adenylate kinase. ADP is a platelet agonist that is secreted from platelet dense granules. It promotes platelet activation through its interaction with ADP receptors P2Y1 and P2Y12. Upon conversion of ADP to adenosine by ecto-ADPases, platelet activation is inhibited via adenosine receptors.

Application

Adenosine 5′-diphosphate sodium salt has been used:

• as a positive control of platelet aggregation to analyze antiplatelet activity of purified disintegrin by aggregometery.
• in the preparation of stock solution for a mito stress test.
• as a positive control in flow cytometry analysis to study the effect of pentameric C-reactive protein (pCRP) and monomeric CRP (mCRP) on the CD62p (P-selectin) expression of platelets.
• as a platelet agonist to stimulate platelet aggregation.

UPC:

12142207

Condition:

New

Weight:

1.00 Ounces

HazmatClass:

No

MPN:

A2754-100MG

CAS:

20398-34-9