AG 957, Adamantyl Ester is a lipophilic, adamantyl ester form of tyrphostin AG 957 that displays anti-proliferative properties. The product has been shown to be selective and is ~3-4 fold more potent than the bcr/abl kinase inhibitor AG 957. AG 957, Adamantyl Ester Downregulates p210bcr/abl autokinase activity (IC|50|= 14 µM). Selectively blocks granulocyte colony formation in CML (chronic myelogenous leukemia) progenitors and inhibits proliferation of K562 cells (IC|50|= 9.8 µM) by inducing apoptosis. AG 957, Adamantyl Ester is reported to retain activity in STI571-resistant and p53-null human leukemia cell lines (IC|50|~0.1-0.25 µM).AG 957, Adamantyl Esteris an ~3-4 fold more potent derivative of AG 957. Specifications and Purity: 98%. Molecular Formula: C24H27NO4. Molecular Weight: 393.48. PubChem CID: 387042. Isomeric SMILES: C1C2CC3CC1CC(C2)(C3)OC(=O)C4=CC=C(C=C4)NCC5=C(C=CC(=C5)O)O. Related Document: https://ald-pub-files.oss-cn-shanghai.aliyuncs.com/aladdinsci/pdp/sds/1/A387504-SCI_c686bd409657a36574ed29fa7745c542.pdf
- UPC:
- 12352108
- Condition:
- New
- Availability:
- 8-12 weeks
- Weight:
- 1.06 Ounces
- HazmatClass:
- No
- WeightUOM:
- LB
- MPN:
- A387504-100mg
- CAS:
- 241127-58-2
- Product Size:
- 100mg
- Precautionary Statement Codes:
- P264
